Table 1. Correlation between clinicopathologic features of spindle cell and sclerosing RMS and MYOD1 mutation.
| Clinicopathologic features | Variable | Frequency (N=21) |
MYOD1 (L122R) |
χ2-value | P- value | |
|---|---|---|---|---|---|---|
| 19.6 (2–66) | Wild | Mutant | ||||
| Age | >18 (adult) | 12 (57%) | 4 (12) | 8(12) | 4.07 | 0.08 |
| ≤18 (pediatric) | 9 (43%) | 7 (9) | 2(9) | |||
| Sex | Male | 18 (86%) | 9 (18) | 9 (18) | 0.28 | 1 |
| Female | 3(14%) | 2 (3) | 1 (3) | |||
| Sites | Head and neck | 11 (52%) | 4 (11) | 7 (11) | 2.37 | 0.19 |
| Other sites | 10 (48%) | 7 (10) | 3 (10) | |||
| Histopathologic subtype | Spindle cell | 12 (57%) | 9 (12) | 3 (12) | 5.74 | 0.03 |
| Sclerosing | 9 (43%) | 2 (9) | 7 (9) | |||
| MYOD1 immunohistochemistry | Positive | 17 (80%) | 7 (17) | 10 (17) | 4.49 | 0.09 |
| Negative | 2 (10%) | 4 (4) | 0 (4) | |||
| Data not available | 2 (10%) | |||||
| Recurrence/Mets | Yes | 10 (47%) | 3 (10) | 7 (10) | 1.9 | 0.34 |
| No | 8 (38%) | 5 (8) | 3 (8) | |||
| Data not available | 3 (14%) | |||||
| Outcome | Alive with disease | 7 (33%) | 2 (7) | 5 (7) | 3.23 | 0.13 |
| Free of disease | 8 (38%) | 6 (8) | 2 (8) | |||
| Data not available | 4 (19%) | |||||
| Recent (FU< 6 months) | 2 (10%) | |||||
Abbreviation: FU: follow up.
Clinicopathologic features, including results of MYOD1 (L122R) mutations in 21 cases of spindle cell and sclerosing rhabdomyosarcomas. Highlighted P-values are statistically significant or of marginal significance.