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. 2016 Jun 28;19(4):349–357. doi: 10.1038/pcan.2016.21

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Copyright © 2016 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Combination of docetaxel and HCI-2509 in (a) PC3 and (b) DU145 cells. Combination index (CI) values were calculated by Chou–Talalay equation using CalcuSyn (BIOSOFT, Great Shelford, Cambridge, UK). Heat map was created using the CI values at various combination doses to show points of synergy (CI<1). Isobologram of CIs in PC3 and DU145 cells in various combinations (c and d).