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. 2016 Jun 28;19(4):349–357. doi: 10.1038/pcan.2016.21

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Copyright © 2016 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Effect of HCI-2509 on docetaxel-resistant PC3D12 cells. Cell viability studies: dose–response curves showing the percent cell viability at the end of 72 h treatment in PC3D12 treated with (a) docetaxel and (b) HCI-2509. Colony formation assays show growth inhibition of colonies (c) and decreased colony size (d) on treatment with HCI-2509. Student's unpaired t-tests, using GraphPad Prism software, were used to calculate two-tailed P-values for each experiment to determine the statistical significance between untreated and treated samples. The statistically significant P-values are labeled in each figure with an asterisk. (e) Western blot analysis shows increased H3K9me2 and decreased c-MYC levels on treatment with HCI-2509.