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β-Receptor effects are nil when INaP and Ih are blocked. A: example ramp protocol I-V curves show that Isop was without effect when applied in the presence of TTX (1 μM) and ZD7288 (100 μM) to block Na+ and Ih currents, respectively. B: example current-clamp trace (spikes truncated) shows that ET cell is hyperpolarized and spontaneous burst is terminated in the presence of TTX and ZD7288 and Isop does not alter membrane potential in the presence of these blockers.
