Table I.
Baseline patient characteristics. Urgent admission was associated with prescribing LMWH as part of TT on discharge. Patients on VKA had significantly higher INR than non-VKA patients
| Parameter | Overall (n = 136) | Group 1 (n = 72) | Group 2 (n = 53) | Group 3 (n = 11) | ANOVA between subgroups |
|---|---|---|---|---|---|
| Atrial fibrillation: | 0.300 | ||||
| Paroxysmal | 93 (68.4) | 46 (63.9) | 38 (71.7) | 9 (81.8) | |
| Permanent | 43 (31.6) | 26 (31.1) | 15 (28.3) | 2 (18.2) | |
| CHA2DS2-VASc [points] | 4.4 ±1.6 | 4.3 ±1.3 | 4.4 ±1.9 | 4.8 ±1.3 | 0.641 |
| Median | 4 | 4 | 4 | 5 | |
| HAS-BLED [points] | 2.5 ±0.9 | 2.5 ±0.8 | 2.5 ±1.0 | 2.7 ±0.8 | 0.639 |
| Median | 2 | 2 | 2 | 3 | |
| Age [years] | 73.3 ±8.6 | 73.3 ±7.7 | 72.5 ±9.2 | 77.0 ±11.0 | 0.286 |
| Sex (male) | 90 (66.2) | 54 (70.8) | 31 (58.5) | 8 (72.7) | 0.315 |
| Admission: | 0.048 | ||||
| Urgent (ACS) | 76 (55.9) | 37 (54.4) | 29 (54.7) | 10 (90.9) | |
| Planned (SA) | 60 (44.1) | 35 (48.6) | 24 (45.3) | 1 (9.1) | |
| Risk factors: | |||||
| Hypertension | 129 (94.9) | 69 (95.8) | 49 (92.5) | 11 (100.0) | 0.506 |
| Hyperlipidemia | 119 (87.5) | 64 (88.9) | 44 (83.0) | 11 (100.0) | 0.263 |
| Diabetes mellitus | 58 (42.6) | 33 (45.8) | 22 (41.5) | 3 (27.3) | 0.499 |
| Previous MI | 65 (47.8) | 34 (47.2) | 22 (41.5) | 9 (81.8) | 0.051 |
| Previous PCI | 53 (39.0) | 31 (43.1) | 17 (32.1) | 5 (45.5) | 0.415 |
| Previous CABG | 23 (16.9) | 15 (20.8) | 7 (13.2) | 1 (9.1) | 0.410 |
| Laboratory data: | |||||
| Creatinine [mg/dl] | 106.3 ±71.0 | 115.0 ±94.1 | 91.9 ±20.8 | 117.1 ±27.7 | 0.176 |
| eGFR [ml/min/1.73 m2] | 66.4 ±19.8 | 66.0 ±22.5 | 69.2 ±14.9 | 55.7 ±18.9 | 0.118 |
| HGB [g/dl] | 13.5 ±1.4 | 13.5 ±1.2 | 13.5 ±1.5 | 13.0 ±2.2 | 0.448 |
| PLT [109/l] | 214.2 ±62.4 | 210.5 ±56.5 | 224.5 ±67.5 | 189.4 ±70.3 | 0.180 |
| INR | 1.4 ±0.6 | 1.6 ±0.7 | 1.1 ±0.2 | 1.2 ±0.4 | < 0.001 |
| Angiographic information: | |||||
| Vessels with > 50% DS | 2.4 ±1.4 | 2.3 ±1.4 | 2.4 ±1.3 | 2.7 ±1.1 | 0.691 |
| Type of procedure: | |||||
| PCI + POBA | 4 (2.9) | 1 (1.4) | 3 (5.7) | 0 (0) | 0.314 |
| PCI + limus-DES | 118 (86.8) | 62 (86.1) | 45 (84.9) | 11 (100) | 0.307 |
| PCI + BMS | 6 (4.4) | 3 (4.2) | 3 (5.7) | 0 (0) | 0.700 |
| OMT | 8 (5.9) | 5 (6.9) | 3 (5.7) | 0 (0) | 0.657 |
| No. of implanted stents | 1.3 ±0.6 | 1.2 ±0.6 | 1.5 ±0.8 | 1.0 ±0.5 | 0.060 |
| Length of stents | 26.5 ±17.8 | 23.6 ±1.4 | 31.2 ±22.4 | 22.4 ±14.8 | 0.066 |
Values are means ± SD or n (%). BMS – bare-metal stent, DES – drug-eluting stent, CABG – coronary artery bypass graft, eGFR – estimated glomerular filtration rate, HGB – hemoglobin, INR – international normalized ratio, LMWH – low molecular weight heparin, MI – myocardial infarction, PCI – percutaneous coronary intervention, PLT – platelets, POBA – plain old balloon angioplasty, OMT – optimal medical treatment, TT – triple therapy, VKA – vitamin K antagonist. Group 1 comprises patients with warfarin/acenocoumarol; group 2 comprises patients with rivaroxaban/dabigatran; group 3 comprises patients with low molecular weight heparin.