Table I.

Detailed results from Nottingham Health Profile (NHP) Questionnaire

Variable	Before RDN	Perioperatively	P-valuea	3 months after RDN	P-valueb	6 months after RDN	P-valuec	12 months after RDN	P-valued	24 months after RDN	P-valuee
Energy	22.2 ±41.0	8.3 ±20.7	0.2	5.6 ±19.3	0.2	8.3 ±20.7	0.3	25.0 ±32.2	0.8	27.8 ±37.2	0.6
Pain	13.5 ±24.7	15.6 ±28.8	0.7	15.6 ±28.8	0.7	15.6 ±28.8	0.7	15.6 ±27.2	0.7	15.6 ±28.8	0.7
Emotional reactions	19.4 ±23.3	9.3 ±13.3	0.02	4.6 ±11.1	0.02	4.6 ±11.1	0.02	5.6 ±11.1	0.02	7.4 ±17.3	0.02
Sleep disturbance	40.0 ±37.2	21.7 ±30.1	0.04	21.7 ±30.1	0.04	23.3 ±30.6	0.07	30.0 ±26.3	0.2	23.3 ±32.8	0.03
Social isolation	1.7 ±5.8	0	0.3	0	0.3	0	0.3	1.7 ±5.8	1	1.7 ±5.8	1
Physical mobility	6.3 ±14.6	9.4 ±17.0	0.3	9.4 ±17.0	0.3	9.4 ±17.0	0.3	10.4 ±16.7	0.2	9.4 ±17.0	0.3
NHP-D	4.2 ±4.7	2.2 ±3.0	0.01	1.7 ±2.9	0.005	1.8 ±2.8	0.006	2.8 ±3.4	0.04	2.8 ±4.5	0.03

Mean values of total score for each section expressed as a percentage and mean values of the NHP index of Distress (NHP-D). Comparison of response before the procedure versus perioperatively and at 3, 6, 12 and 24 months after renal denervation (RDN)

^aBefore RDN vs. perioperatively

^bbefore RDN vs. 3 months after RDN

^cbefore vs. 6 months after RDN

^dbefore vs. 12 months after RDN

^ebefore vs. 24 months after RDN