Table 1. Characteristics of NSCLC and COPD patients included in the cytokine/MMP analysis.

Variable	NSCLC cohort		COPD cohort		P-value
	N=43	%	N=35	%
Age at inclusion (years)
Mean/median/range	69/70/47–88		71/72/50–87		0.333a
Sex
Male	31	72.1	14	40.0	0.006b
Female	12	27.9	21	60.0
Smoking history
Current	11	25.6	13	37.1	0.057c
Former	32	74.4	19	54.3
Never	0	0	3	8.6
Pack years
Mean/median/range	34/30/4–144		32/35/12–60		0.698a
Use of systemic steroids
Yes	14	32.6	4	11.4	0.153b
No	29	67.4	31	88.6
COPD grade
I			1	2.9
II			10	28.6
III			16	45.7
IV			8	22.8
ECOG performance status
0	8	18.6
1	22	51.2
2	13	30.2
Stage
III	11	25.6
IV	32	74.4
Histology
Adenocarcinoma	26	60.5
Squamous cell carcinoma	13	30.2
NOS	4	9.3
Previous chemotherapy
Yes	17	39.5
No	26	60.5

Abbreviations: COPD, chronic obstructive pulmonary disease; ECOG, Eastern Cooperative Oncology Group; MMP, matrix metalloproteinase; NOS, not otherwise specified; NSCLC, non-small cell lung cancer.

^aTwo sided t-test for continuous variables.

^bFisher's exact test for categorical variables.

^cChi-square test for categorical variables.