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. 2016 Nov 4;48(11):e269. doi: 10.1038/emm.2016.119

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Copyright © 2016 The Author(s)

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Metabolic targets at a glance. GLUTs, HK2, PFK2, PKM2, LDH, PDK and MCT4 shown in red can be upregulated from stabilization of HIF-1α. Representative inhibitors of metabolic nodes entering clinical trials are shown in bold. ACC, acetyl-CoA carboxylase; AGE, advanced glycation end product; CPT-1, carnitine palmitoyltransferase 1; FAT, fatty acid translocase; G3P, glyceraldehyde 3-phosphate; GLS, glutaminase; GLUT, glucose transporter; HK2, hexokinase 2; LCFA, long chain fatty acid; LCFacyl-CoAs, long chain fatty acyl-CoAs; MCT, monocarboxylate transporter; PEP, phosphoenolpyruvate; PDH, pyruvate dehydrogenase; PDK, pyruvate dehydrogenase kinase; PFK, phosphofructokinase; PS, pyruvate symporter; SLC5A1, sodium glucose co-transporter; TAG, triacylglyceride; TCAT, tricarboxylic acid transporter; 2-DG, 2-deoxyglucose; 2PG, 2-phosphoglycerate; 3PG, 3-phosphoglycerate.