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. 2016 Nov 4;48(11):e267. doi: 10.1038/emm.2016.95

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Copyright © 2016 KSBMB.

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Effects of dextran sulfate sodium (DSS) treatment on body weight and survival of wild-type (WT) and transglutaminase 2-deficient (TG2^−/−) mice. (a, b) WT and TG2^−/− mice (14-week-old females) were fed ad libitum water containing 0% (n=2) and 2% (n=8) DSS for 7 days. (c, d) Age- and sex-matched WT and TG2^−/− mice were fed ad libitum water containing 2% (n=14) and 3.5% (n=15) DSS for 8 and 6 days, respectively, or plain water (n=6). (a, c) Body weight was analyzed in the mice survived at the indicated time points and the value expressed as percentage of weight on the day of first exposure to DSS is plotted against time. Data are presented as the mean±s.e.m. Overall P-values analyzed using two-way analysis of variance (ANOVA) are shown at the right; individual Bonferroni post-test results are shown above the line profiles. (b, d) Survival curves of WT and TG2^−/− mice are depicted against time. The P-values were calculated using the log-rank test. *P<0.05; **P<0.01; ***P<0.001; NS, not significant.