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. 2016 Nov 4;48(11):e267. doi: 10.1038/emm.2016.95

Figure 5.

Figure 5

In vivo intestinal permeability and myeloperoxidase activity in colon of dextran sulfate sodium (DSS)-treated wild-type (WT) and tansglutaminase 2-deficient (TG2−/−) mice. Age- and sex-matched WT and TG2−/− mice were administered 2% DSS water for 7 days and water for an additional 3 days or 3.5% DSS water for 5 days. (a) Mice were gavaged with fluorescein isothiocyanate (FITC)–dextran (60 mg per 100 g of body weight), and serum FITC–dextran levels were quantified and graphed as the mean and s.d. values for each group (n=3 for each group). (b) Mice were killed, and myeloperoxidase activity was measured in distal colons. The activity was graphed as the mean±s.e.m. values for each group (n=3 for each group). Data are representative of at least two experiments. Overall P-values analyzed using two-way analysis of variance (ANOVA) are shown; individual Bonferroni post-test results are shown above the columns. ***P<0.001; NS, not significant.