Table 3.
Genes distinguishing SLE flare from SLE infection; results of differential expression analysis following Benjami-Hochberg multiple testing comparison
| Gene symbol | Gene name | Log fold change (FC) |
p Value | Adj p* |
|---|---|---|---|---|
| IFIT1 | IFN-induced protein with tetricopeptide repeats 1 | 0.75 | 1.62E-05 | 0.04 |
| OTOF | Otoferlin | 0.69 | 1.52E-05 | 0.04 |
| Fli-1 | Friend leukaemia virus integration 1 | 0.40 | 7.96E-06 | 0.04 |
| PRKAG2 | Protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 0.30 | 1.54E-05 | 0.04 |
| CNOT8 | CCR4-NOT transcription complex, subunit 8 | 0.28 | 1.5E-05 | 0.04 |
| MYL5 | Myosin, light chain 5, regulatory | −0.21 | 1.19E-05 | 0.04 |
| CXorf21 | Chromosome X, open reading frame 21 | 0.18 | 1.1E-06 | 0.033 |
| IFI44L | Interferon-induced protein-44 like | 1.11 | 1.52E-05 | 0.04 |
Note that 7/8 genes are upregulated in SLE flare; MYL5 is the only gene significantly expressed in SLE infection compared with SLE flare.
SLE, systemic lupus erythematosus.