Table 2.
Characteristics of patients with RA with and without anti-cTNC5 antibodies
| Anti-cTNC5 negative RA (n=60) |
Anti-cTNC5 positive RA (n=41) |
p Value | |
|---|---|---|---|
| Female, n (%) | 33 (55) | 25 (60.1) | 0.682 |
| Age (years) | 55.2±16.1 | 56.1±13.3 | 0.785 |
| Symptom duration (days) | 52.3±21.5 | 56±21.5 | 0.400 |
| CRP (mg/dL) | 10.5 (0–43) | 18 (6–39) | 0.062 |
| ESR (mm/hour) | 18 (11–45) | 25 (19–46) | 0.372 |
| DAS28 (CRP) | 4.26±1.4 | 4.55±1.4 | 0.320 |
| DAS28 (ESR) | 4.51±1.5 | 4.82±1.6 | 0.320 |
| 28 TJC | 7.22±6.5 | 9.1±10.4 | 0.267 |
| 28 SJC | 7.6±7.2 | 6.9±5.5 | 0.595 |
| Smoking, n (%) | |||
| Ever smoker | 34/56 (60.7) | 21/40 (52.5) | 0.682 |
| Never-smoker | 22/56 (39.3) | 19/40 (47.5) | 0.374 |
| Anti-CCP positive, n (%) | 9 (15) | 39 (95.1) | <0.0001 |
| RF IgG positive, n (%) | 16 (26.7) | 37 (90.2) | <0.0001 |
| RF IgA positive, n (%) | 10 (16.6) | 23 (56.1) | <0.0001 |
Data are shown as number (percentage), mean±SD, or median (IQR) as appropriate. Comparisons have been performed with χ2, Student's t-test and Mann Whitney U test for categorical, parametric continuous and non-parametric continuous data, respectively.
CCP, cyclic citrullinated peptide; CRP, C reactive protein; cTNC, citrullinated tenascin-C; DAS, disease activity score; ESR, erythrocyte sedimentation rate; RA, rheumatoid arthritis; RF, rheumatoid factor; SJC, swollen joint count; TJC, tender joint count.