Table 3.
Selected studies associating right heart metrics with survival in pulmonary hypertension.
| Study | Population | Number of patients |
Outcomes | Afterload metrics* |
Right ventricular metrics* |
Comments |
|---|---|---|---|---|---|---|
| NIH registry | ||||||
| D’Alonzo et al. 1991 (27) |
PAH | 194 | Death or heart- lung transplant during FU (2.8 years) |
MPAP Mean right atrial pressure |
Cardiac Index | Does not reflect the current survival rate Only applicable to naïve-treatment patients |
| Pulmonary Hypertension Connection registry | ||||||
| Thenappan et al. 2010 (28) |
PAH | 578 | Death during FU (3.9 years) |
MPAP Mean right atrial pressure |
Cardiac Index | Does not reflect the recent treatments available |
| French National registry | ||||||
| Humbert et al. 2010 (29) | Idiopathic, familial, drug and toxins- associated PAH |
354 | Death at 3 years | - | Cardiac Index | |
| REVEAL Registry | ||||||
| Benza et al. 2010 (30) |
Idiopathic, familial, CHD and CTD- Associated PAH |
2,716 | Death at 1 year | Pulmonary Vascular Resistance (> 32 Wood Units) |
Pericardial effusion Mean right atrial pressure (>20mmHg) |
|
| UK registry | ||||||
| Lee et al. 2012 (31) |
Idiopathic, familial, CHD and CTD associated PAH |
182 | Death at 1 and 2 years | - | Mean right atrial pressure | |
| Right Heart score | ||||||
| Haddad et al. 2015 (10) |
Idiopathic, familial, drug and toxins associated PAH |
95+87 | Death or lung transplant at 5 years |
- | RV dysfunction Severe RA enlargement Systemic blood pressure <110mmHg |
Simple Echocardiographic score in PAH |
| Others | ||||||
| Mahapatra et al. 2006 (32) |
Idiopathic PAH |
104 | Death at 4 years | Capacitance | - | |
| Haddad et al. 2011 (33) |
PAH admitted for acute right heart failure |
119 | Death or lung transplant at 90 days |
- | TR severity per grade |
Rare study on acutely deteriorated patients with PH |
| Fine et al. 2013 (12) |
Group 1, 3 and 4 PH vs. no PH |
406 + 169 | Death at 18 months |
None retained | Peak RV longitudinal strain Pericardial effusion Log (NT- proBNP) |
Large study on prognostic value of RV strain in PAH |
*
In multivariate analysis. CHD: congenital heart disease; CTD: connective tissue disease; MPAP: mean pulmonary arterial hypertension; PAH: pulmonary arterial hypertension; RV: right ventricle; TR: tricuspid regurgitation. For other abbreviations, see Table 2.