Table 1.

Studies of safety and tolerability of ivermectin incorporating dosages greater than or equal to 800 mcg/kg.

Reference	Highest single dose	Participants with single dose ≥800 mcg/kg, n	Total study population, n	Single doses in mcg/kg (n)	Adverse events: increased vs control
Awadzi 1995, 1999 [22,23]	800 mcg/kg	36	100 adult males with onchocerciasis in Ghana	150 (15), 400a (25), 600a (24), 800a (24), 800b (12)	No
Guzzo 2002 [24]	2000 mcg/kg	36	68 healthy adults, non-pregnant, in the United States	0 (17), 500c (15), 1000c (12), 1500 (12), 2000 (12)	No
Kamgno 2004 [25-27]	800 mcg/kg	330	657 adult males with onchocerciasis in Cameroon	150d (327), 800d,e (330)	Transitory mild visual side effects, without structural abnormalities upon ophthalmological exam

^aPreceded 3 days earlier by 150 mcg/kg or placebo.

^bPreceded 13 days earlier by 800 mcg/kg.

^cRepeated 3 times a week (days 1, 4, and 7).

^dRepeated 3 times monthly or once yearly.

^ePreceded 3 or 12 months earlier by 400 mcg/kg.