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. 2016 Nov 23;6(11):160293. doi: 10.1098/rsob.160293

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© 2016 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 8. — Transcriptional profile of non-activated R7-I, R7-II and R7-III CD8 T cells. (a) Row centred heatmap of transcripts per million (TPM) values for genes with a significant expression difference of over twofold between R7-III and R7-II homozygous CD8 T cells. (b) Ingenuity pathway of genes associated with cell cycle progression and found to be significantly differentially expressed between R7-I and R7-III homozygous CD8 T cells. (c) Sample correlation matrix for R7-I, R7-II and R7-III CD8 T cells generated from TPM values for expressed genes (assumed to have a minimum TPM of 1 across all samples in the experiment). Each row and column represents a replicate biological sample of the denoted Rop7 clones. (d) CD5 versus Ki-67 expression gated on CD8 T cells from WT BALB/c mice.