Table 1. Participant baseline characteristics demonstrating that there were no significant differences in patient demographics between the treatment and historical control groups.
| Characteristics | Treatment (n = 109 eyes) (%) | Control (n = 79 eyes) (%) | P value |
|---|---|---|---|
| Age (years): Mean ± SD (Range) | 45.4 ± 19.3(16–82) | 53.7 ± 14.1(26–81) | 0.13 |
| ≤40 years | 18 (16.5) | 7 (8.9) | |
| >40 years | 91 (83.5) | 72 (91.1) | |
| Sex: | 0.26 | ||
| Male | 63 (57.8) | 36 (45.6) | 0.47 |
| Female | 46 (42.2) | 43 (54.4) | 0.2 |
| Diagnosis | 0.39 | ||
| -Chemical/thermal injuries | 29 (26.6) | 18 (22.8) | |
| -Neurotrophic keratopathy | 25 (22.9) | 30 (38.0) | |
| -Postinfectious persistent epithelial defects | 15 (13.8) | 9 (11.4) | |
| -Stevens-Johnson syndrome/toxic epidermal necrolysis | 11 (10.1) | 4 (5.1) | |
| -Bullous keratopathy | 6 (5.5) | 3 (3.8) | |
| -Contact lens-related limbal stem cell deficiency | 6 (5.5) | 2 (2.5) | |
| -Recurrent corneal erosion | 5 (4.6) | 3 (3.8) | |
| -Vernal keratoconjunctivitis with shield ulcer | 4 (3.7) | 2 (2.5) | |
| -Mucous membrane pemphigoid | 3 (2.6) | 1 (1.3) | |
| -Exposure keratopathy | 3 (2.6) | 1 (1.3) | |
| -Graft-versus-host disease | 1 (0.9) | 1 (1.3) | |
| -Unknown cause limbal stem cell deficiency | 1 (0.9) | — | |
| -Severe dry eye | — | 4 (5.1) | |
| -Aniridia keratopathy | — | 1 (1.3) | |
| Diabetes mellitus | 34 (31.2) | 21 (26.6) | 0.47 |
| Prior contact lens use | 73 (67.0) | 45 (57.0) | 0.020 |
n = number, SD = standard deviation.