Table 2.

Results of the SNVs with the smallest p values in the association tests of H ₀ : β ₁ = 0 for GE under the copula and univariate models

SNV	MAF	Location	Copula			Univariate
			$\widehat{{\mathit{\beta }}_1}$ (SE)	p value	Adj. p value	$\widehat{{\mathit{\beta }}_1}$ (SE)	p value	Adj. p value
rs2314667	0.32	UBA52 (upstream)	0.88 (5.42 × 10− 02)	6.47 × 10− 60	1.71 × 10− 55	0.88 (5.49 × 10− 02)	3.21 × 10− 26	8.71 × 10− 22
rs2314664	0.33	UBA52 (downstream)	0.85 (5.52 × 10− 02)	5.01 × 10− 54	7.97 × 10− 50	0.85 (5.59 × 10− 02)	7.24 × 10− 25	1.18 × 10− 20
rs2314666	0.34	UBA52 (downstream)	0.85 (5.66 × 10− 02)	2.88 × 10− 51	3.81 × 10− 47	0.85 (5.73 × 10− 02)	3.41 × 10− 24	4.62 × 10− 20

Adj. p value is the adjusted p value with BH-correction; MAF denotes the minor allele frequency in this sample. The estimated Kendall’s τ between SBP _adj and GE _UBA52,adj is − 0.01. Note: The markers in the table are in very high linkage disequilibrium (LD) (with 0.96 ≤ r ≤ 0.99). SNVs rs6554 and rs10425018 in the same gene are in perfect LD with rs2314667 and have identical association; also rs7258480 is in perfect LD with rs2314664