Table 2.
Top 20 variants influencing simulated SBP and DBP in the GAW20 unrelated exome sample, in decreasing order of variance explained
| Chromosome | Position (bp) | Gene | Frequency of non-reference allele | Betaa DBP | Betaa SBP | DBP variance explained (%) | SBP variance explained (%) |
|---|---|---|---|---|---|---|---|
| 3 | 47956424 | MAP4 | 0.34354 | −3.93 | −6.09 | 7.88 | 7.01 |
| 1 | 175092674 | TNN | 0.64771 | 3.38 | 4.10 | 5.89 | 3.20 |
| 1 | 66075952 | LEPR | 0.15466 | 3.49 | 3.78 | 3.61 | 1.56 |
| 3 | 48040283 | MAP4 | 0.02805 | −5.03 | −7.80 | 1.56 | 1.39 |
| 3 | 47957996 | MAP4 | 0.02290 | −4.41 | −6.84 | 0.98 | 0.87 |
| 1 | 151501841 | CGN | 0.10396 | −2.63 | 0 | 1.46 | 0 |
| 13 | 28624294 | FLT3 | 0.61400 | 1.40 | 1.44 | 1.05 | 0.41 |
| 3 | 48040284 | MAP4 | 0.00695 | −5.05 | −7.83 | 0.40 | 0.36 |
| 1 | 175092637 | TNN | 0.02007 | 3.38 | 4.10 | 0.51 | 0.28 |
| 1 | 151491026 | CGN | 0.02084 | −2.88 | 0 | 0.38 | 0 |
| 1 | 175046835 | TNN | 0.01390 | 2.88 | 3.49 | 0.26 | 0.14 |
| 3 | 47908815 | MAP4 | 0.00257 | −4.99 | −7.73 | 0.15 | 0.13 |
| 11 | 77937768 | GAB2 | 0.00386 | 0 | 6.04 | 0 | 0.12 |
| 1 | 175046652 | TNN | 0.00824 | 3.35 | 4.06 | 0.20 | 0.11 |
| 9 | 123605126 | PSMD5 | 0.18837 | −0.58 | −0.89 | 0.11 | 0.10 |
| 3 | 58109162 | FLNB | 0.45677 | 0.13 | 0.64 | 0.01 | 0.08 |
| 1 | 151503071 | CGN | 0.01132 | −2.88 | 0 | 0.21 | 0 |
| 1 | 175054626 | TNN | 0.00566 | 3.30 | 4.00 | 0.14 | 0.08 |
| 1 | 53712727 | LRP8 | 0.21410 | 0 | −0.71 | 0 | 0.07 |
| 19 | 46812451 | HIF3A | 0.03886 | 1.36 | 0.92 | 0.16 | 0.03 |
aBeta = change in mean phenotype value per non-reference allele carried