Table 2.
Power to detect single SNP associations using SOLAR-MGA and FaST-LMM, for MAP4 simulated GAW19 pedigree data
| Simulated diastolic blood pressure | |||||
| Chr–Bp | Prop. of variance explained/MAF/beta | SOLAR MGA power | FaST-LMM power | ||
| Alpha = 0.05 | Alpha = 5 × 10−8 | Alpha = 0.05 | Alpha = 5 × 10−8 | ||
| 3 – 48040283 | 0.023/.03/-6.2 | 1 | 0.99 | 1 | 0.99 |
| 3 – 47957996 | 0.012/.03/-4.6 | 1 | 0.99 | 1 | 0.98 |
| 3 – 47956424 | 0.012/.37/-1.5 | 0.99 | 0.04 | 0.99 | 0.02 |
| 3 – 48040284 | 0.009/.01/-7.0 | 0.69 | 0 | 0.58 | 0 |
| 3 – 47913455 | 0.004/.005/-5.5 | 0.52 | 0 | 0.58 | 0 |
| 3 – 47957741 | 0.002/.002/-5.1 | 0.13 | 0 | 0.06 | 0 |
| Simulated systolic blood pressure | |||||
| Chr–Bp | Proportion of variance Explained/MAF/beta | SOLAR-MGA power | FaST-LMM power | ||
| Alpha = 0.05 | Alpha = 5 × 10-8 | Alpha = 0.05 | Alpha = 5 × 10-8 | ||
| 3 – 48040283 | 0.028/.03/-9.9 | 1 | 0.99 | 1 | 0.99 |
| 3 – 47957996 | 0.015/.03/-7.4 | 1 | 0.99 | 1 | 0.99 |
| 3 – 47956424 | 0.014/.37/-2.4 | 0.99 | 0.03 | 0.98 | 0.01 |
| 3 – 48040284 | 0.011/.01/-11.1 | 0.77 | 0 | 0.66 | 0 |
| 3 – 47913455 | 0.004/.005/-8.7 | 0.48 | 0 | 0.56 | 0 |
| 3 – 47957741 | 0.003/.002/-8.1 | 0.12 | 0 | 0.09 | 0 |
Chr chromosome, Bp base pair, MAF minor allele frequency