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. 2016 Oct 18;10(Suppl 7):371–377. doi: 10.1186/s12919-016-0058-1

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Comparison of the estimated effects (a–c), standard errors (d–f), and -log₁₀ of the 1DF p values (g–i) on SBP from the interaction model (x-axis) and med-diff (y-axis) approaches in up to 200 replicates of simulated gene–medication interactions at 3 SNPs at CYP3A43 (6.2 mm Hg, dashed line in (a–c) of varying minor allele frequencies (MAFs)