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. 2016 Oct 18;10(Suppl 7):371–377. doi: 10.1186/s12919-016-0058-1

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Comparison of the false-positive proportions (FPPs) and 95 % confidence intervals for the interaction model (solid line) and med-diff approaches (dashed line) and 200 replicates of true negative findings on the odd-numbered chromosomes using the 1DF (gray) and 2DF tests (black) across bins of minor allele frequency (>0.1 to 50 %). Note: False-positive proportions were calculated after excluding SNPs at the CYP3A43 locus (chr7:98957518 to 99957518)