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. 2016 Dec 2;6:37850. doi: 10.1038/srep37850

Figure 2. The antinociceptive effect of pretreatment with l-THP (20 nmol for i.p and 2 nmol for i.t), Sig-1R antagonist BD1047 (BD, 30 nmol, i.t) on the repeated i.t treatment of Sig-1R agonist, PRE084 (PRE)-induced changes in the paw withdrawal frequency (%).

Figure 2

(A) On the time course curves. BD, *P < 0.05 and ***P < 0.001; l-THP, i.p, ##P < 0.01 and ###P < 0.001; l-THP, i.t, +P < 0.05 and +++P < 0.001 as compared with vehicle treated group. (B) The mean of area under curve of the Sig-1R induced mechanical allodynia was also significantly reduced by BD or l-THP pretreatment. (n = 10–11 per group) **P < 0.01 as compared with that of the vehicle group.