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. 2016 Dec 2;6:38491. doi: 10.1038/srep38491

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Copyright © 2016, The Author(s)

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(a) HE staining showed that the bone trabecula was thinner, sparser, smaller, and more commonly fractured and disordered in the Model group compared with the Control group. (b) The microarray analysis identified 37 differentially expressed miRNAs in the Model group. (c) qRT-PCR detected a significant down-regulation of miR-27a in the Model group. (d) qRT-PCR detected the up-regulation of miR-182 in the Model group. (e, f) qRT-PCR detected a significant up-regulation of the PPARγ and GREM1 mRNAs in the Model group. (g, h) The PPARγ and GREM1 mRNA levels were negatively correlated with miR-27a expression. ^*P < 0.05.