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. 2016 Dec 2;6:38266. doi: 10.1038/srep38266

Figure 1. Deletion or blockade of Panx1 prevents tactile hypersensitivity in an orofacial pain model.

Figure 1

Time course of changes of submandibular skin (SMS) tactile threshold of WT and Panx1 null mice (A) following CFA injection into SMS and the normalized values (post/pre-CFA injection) of SMS tactile threshold (B) shown in part (A). Histograms of the mean ± SE values of SMS (C) and paw (D) tactile threshold obtained before (0 days) and at 21 days post-CFA injection into the SMS. (E,F) show the mean ± SE of SMS and paw tactile threshold of WT mice injected with mefloquine (MFQ) or vehicle after saline or CFA injections into SMS. (A and B): n = 16-24 mice, *P < 0.05 for one-way ANOVA with repeated measures. (C–F): **P < 0.001, one-way ANOVA followed by Tukeys’ multiple comparison tests; number of mice indicated above bars in histogram.