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. 2016 Dec 2;6:38266. doi: 10.1038/srep38266

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Time course of changes of submandibular skin (SMS) tactile threshold of (A left) Panx1^fl/fl, (B left) GFAP-Cre:Panx1^fl/fl, and (C left) NFH-Cre:Panx1^fl/fl following CFA injection into the submandibular skin; (A–C right) are the normalized values (post/pre-CFA injection) of SMS tactile threshold shown in part A. Histograms of the means ± SE values of SMS (D) and hind paw (E) tactile threshold obtained before (0 days) and at 28 days post-CFA injection into the submandibular skin. Parts A–C: *P < 0.05, **P < 0.01, ***P < 0.001 from one-way ANOVA with repeated measures. Parts D-E: *P < 0.05, ***P < 0.001, One-way ANOVA followed by Tukeys’ multiple comparison tests. Number of mice indicated. FF: Panx1^fl/fl, GF: GFAP-Cre:Panx1^fl/fl; NF: NFH-Cre:Panx1^fl/fl; 0 and 28 indexes: before and 28 days after CFA injection, respectively.