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. 2016 Dec 2;6:38266. doi: 10.1038/srep38266

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Tactile sensitivity was assessed before injection of saline or CFA using von Frey filaments to determine baseline tactile sensitivity. Each point represents SMS tactile threshold obtained for each mouse measured with von Frey filaments before injection of either saline or CFA, and the range bars represent mean ± SE values of SMS tactile threshold obtained for each genotype. Note that mice with NFH-Cre targeted deletion show higher mean and a wider range of variability in tactile threshold values. WT: wild type, Panx1 null, Panx1 FF: Panx1^fl/fl, GFAP-Cre: GFAP-Cre:Panx1^fl/fl, NFH: NFH-Cre:Panx1^fl/fl. n = number of animals.