Figure 1. 5hmC is depleted and uniquely distributed in glioblastoma.

(a) Empirical cumulative distribution of mean 5-hydroxymethylcytosine (5hmC) and 5-methylcytosine (5mC) across thirty glioblastomas. (b) Cumulative proportions of Spearman correlation coefficients calculated for CpG-specific across thirty glioblastomas. (c) Percentiles of mean 5mC beta-values for glioblastomas (n=30) across CpG Island strata. Percentiles (that is, quintiles) shown were selected arbitrarily to highlight a large range of values and significant differences between beta-values across the genomic regions at these percentiles were evaluated by Kruskal-Wallis hypothesis tests. Statistical significance (P<8.3E-03, Bonferroni adjusted alpha) is indicated with a *. (d) Percentiles of mean 5hmC in glioblastomas (n=30) across CpG Island strata with statistical assessment via Kruskal-Wallis tests.