Skip to main content
. 2016 Nov 25;7:13177. doi: 10.1038/ncomms13177

Figure 6. Glioblastoma 5hmC clusters are associated with survival.

Figure 6

(a) Recursively Partitioned Mixture Model (RPMM) of tumour samples based on highest 5hmC CpGs (n=3,876 CpGs). In the heat map, each row represents a single CpG and each column represents a single tumour sample. Low and High 5-hydroxymethylcytosine profile clusters are indicated by colour (Low 5hmC=red, High 5hmC=blue) and are separated by a dotted red line. Total 5hmC content (quantified by the mean level of 5hmC within each tumour sample) and subject age are presented as continuous variables with intensity of colour representing the minimum and maximum values in the population of glioblastomas (n=30). Cluster membership was associated with total 5hmC amount (P=2.0E-04, Kruskal-Wallis rank sum test), and patient age (P=0.03, Kruskal-Wallis rank sum test). (b) Kaplan-Meier survival plot for RPMM clusters of low 5hmC and high 5hmC. (c) Multivariate Cox proportional hazard ratios for survival based on RPMM cluster membership adjusted for subject age and sex.