Table 1.
Demographic data, clinical data, MRS NAA measurements, and MRI 3D-FD measurements derived from controls and SCA3 patients.
| Variables | Control (n = 40) | SCA3 (n = 40) | SCA3 |
SCA3 |
p-Value |
|---|---|---|---|---|---|
| CAG < 74 (n = 22) | CAG ≥ 74 (n = 18) | ||||
| Age of onset (AO) (year) | ND | 38.1 ± 10.9 | 44.9 ± 9.5 | 29.9 ± 5.6 | < 0.001⁎⁎⁎ |
| Duration (year) | ND | 7.7 ± 5.0 | 7.8 ± 5.6 | 7.7 ± 4.4 | 0.962 |
| SARA | ND | 14.2 ± 8.6 | 13.8 ± 8.2 | 14.8 ± 9.3 | 0.725 |
| CAG repeat length | ND | 73.2 ± 4.0 | 70.3 ± 2.4 | 76.7 ± 2.4 | < 0.001⁎⁎⁎ |
| SARA/Duration (year) | ND | 2.2 ± 1.3 | 2.3 ± 1.4 | 2.1 ± 1.3 | 0.634 |
| MRS study: | |||||
| Age (year) | 51.20 ± 17.58 | 45.9 ± 11.9 | 52.7 ± 10.8 | 37.6 ± 6.9†† | < 0.001⁎⁎⁎ |
| M/F | 20/20 | 20/20 | 10/12 | 10/8 | 0.526a |
| Rt-Cb-NAA | 1.00 ± 0.11 | 0.82 ± 0.15††† | 0.79 ± 0.17††† | 0.85 ± 0.12††† | 0.172 |
| Lt-Cb-NAA | 1.00 ± 0.13 | 0.85 ± 0.15††† | 0.81 ± 0.13††† | 0.91 ± 0.16† | 0.043⁎ |
| V-NAA | 0.90 ± 0.11 | 0.78 ± 0.10††† | 0.76 ± 0.08††† | 0.81 ± 0.12†† | 0.196 |
| MRI study: | |||||
| Age (year) | 43.5 ± 11.2 | 45.9 ± 11.9 | 52.7 ± 10.8†† | 37.6 ± 6.9† | < 0.001⁎⁎⁎ |
| M/F | 20/20 | 20/20 | 10/12 | 10/8 | 0.526a |
| Lt-A-FD | 2.12 ± 0.04 | 2.08 ± 0.08†† | 2.07 ± 0.07††† | 2.10 ± 0.08 | 0.168 |
| Rt-A-FD | 2.10 ± 0.04 | 2.02 ± 0.08††† | 1.99 ± 0.08††† | 2.05 ± 0.07†† | 0.007⁎⁎ |
| Lt-PU-FD | 2.43 ± 0.02 | 2.42 ± 0.04 | 2.43 ± 0.03 | 2.41 ± 0.05 | 0.319 |
| Rt-PU-FD | 2.43 ± 0.02 | 2.41 ± 0.04† | 2.40 ± 0.04†† | 2.41 ± 0.05 | 0.565 |
| Lt-PL-FD | 2.34 ± 0.04 | 2.32 ± 0.06† | 2.33 ± 0.04 | 2.31 ± 0.08† | 0.307 |
| Rt-PL-FD | 2.36 ± 0.03 | 2.36 ± 0.06 | 2.37 ± 0.04 | 2.34 ± 0.08 | 0.307 |
| V-FD | 2.16 ± 0.05 | 2.14 ± 0.05 | 2.14 ± 0.05 | 2.14 ± 0.06 | 0.997 |
| Cb-FD | 2.51 ± 0.02 | 2.48 ± 0.04††† | 2.48 ± 0.03††† | 2.47 ± 0.05†† | 0.949 |
SARA: SARA score, Rt: right, Lt: left, Cb: cerebellar, V: vermis, NAA: NAA/Cr ratio, Lt-A-FD: left anterior lobe FD, Rt-A-FD: right anterior lobe FD, Lt-PU-FD: left posterior upper lobe FD, Rt-PU-FD: right posterior upper lobe FD, Lt-PL-FD: left posterior lobe FD, Rt-PL-FD: right posterior lobe FD, V-FD: vermis FD, Cb-FD: FD of the whole cerebellum.
p < 0.05 represents significant difference compared with controls.
p < 0.01 represents significant difference compared with controls.
p < 0.001 represents significant difference compared with controls.
p < 0.05 represents significant difference between the two SCA3 subgroups.
p < 0.01 represents significant difference between the two SCA3 subgroups.
p < 0.001 represents significant difference between the two SCA3 subgroups.
Chi-squared test.