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. 2016 Nov 25;7:13572. doi: 10.1038/ncomms13572

Figure 7. GAT-3-mediated EPSC inhibition depends on astrocytic Ca2+ signalling and ATP/adenosine release.

Figure 7

(a) A1 antagonist DPCPX (10 μM) increases amplitude of EPSCs and occludes the effect of SNAP5114 (n=6 cells from 4 animals). (b) In all, 30 μM GABA in the presence of DPCPX does not alter EPSC amplitude (n=7 cells from 4 animals). (c) Summary plot showing the effects of DPCPX alone, and SNAP5114 and GABA in the presence of DPCPX on normalized EPSC amplitudes. Error bars represent s.e.m.'s, *** P<0.001 (paired t-test compared with baseline).