Figure 3. Cys275 oxidation is responsible for NPM1 translocation.
(a–c) Translocation of mCherry-NPM1 WT and EGFP-NPM1 mutants in identical cells upon H2O2 (500 μM) exposure, visualized by live-cell imaging for 20 min. (d) Localization of various FLAG-NPM1 mutants in unstressed HeLa cells. Scale bars, 5 μm. 3C/S, C21/104/275S.
