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. 2016 Nov 25;7:13599. doi: 10.1038/ncomms13599

Figure 3. Cys275 oxidation is responsible for NPM1 translocation.

Figure 3

(ac) Translocation of mCherry-NPM1 WT and EGFP-NPM1 mutants in identical cells upon H2O2 (500 μM) exposure, visualized by live-cell imaging for 20 min. (d) Localization of various FLAG-NPM1 mutants in unstressed HeLa cells. Scale bars, 5 μm. 3C/S, C21/104/275S.