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. 2016 Nov 25;7:13599. doi: 10.1038/ncomms13599

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Nucleolar oxidation is a general response to various cellular stresses. During nucleolar oxidation, NPM1 undergoes S-glutathionylation on Cys²⁷⁵, which triggers the dissociation of NPM1 from nucleolar nucleic acids. The nucleoplasmic NPM1 is indispensible for p53 activation induced by nucleolar stress.