Table 1. The K D values of the interactions of rRNA or rDNA G-quadruplexes with NPM1-C70 WT or C275S mutants respectively.
| Ligand (oligo) | Analyte (NPM1) |
KD (μg ml−1) |
|
|---|---|---|---|
| Vehicle | GSSG | ||
| G4-DNA | C70-WT | 5.514±2.018 | 1.824±0.297 |
| C70-C275S | 4.988±1.530 | 5.684±1.307 | |
| G4-RNA | C70-WT | 3.158±1.038 | 0.8101±0.574 |
| C70-C275S | 2.613±0.875 | 3.112±1.049 | |
G4, G-quadruplex, GSSG, oxidized glutathione.