Table 2.
Unadjusted and adjusted linear regression analyses between MDD status and forearm, spine, total body and total hip BMD (g/cm2).
| Univariate models | Multivariable model 1 | Multivariable model 2 | Final model | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BMD/MDD status | B | 95% CI | P value | B | 95% CI | P value | B | 95% CI | P value | B | 95% CI | P value |
| Forearm | ||||||||||||
| (Constant) | 0.418 | 0.413, 0.422 | <.001 | 0.352 | 0.323, 0.380 | <.001 | 0.360 | 0.331, 0.390 | <.001 | 0.475 | 0.362, 0.587 | <.001 |
| Single MDD | 0.018 | 0.003, 0.032 | .016 | 0.009 | -0.004, 0.022 | .19 | 0.010 | -0.003, 0.024 | .15 | 0.011 | -0.003, 0.024 | .11 |
| Recurrent MDD | -0.009 | -0.027, 0.010 | .36 | -0.018 | -0.035, -0.001 | .038 | -0.019 | -0.036, -0.001 | .037 | -0.020 | -0.038, -0.002 | .033 |
| Lumbar spine | ||||||||||||
| (Constant) | 1.298 | 1.284, 1.311 | <.001 | 0.907 | 0.812, 1.002 | <.001 | 0.929 | 0.831, 1.026 | <.001 | 0.608 | 0.241, 0.974 | .001 |
| Single MDD | -0.016 | -0.062, 0.029 | .48 | -0.007 | -0.051, 0.037 | .75 | -0.003 | -0.047, 0.042 | .91 | 0.005 | -0.040, 0.049 | .83 |
| Recurrent MDD | -0.053 | -0.110, 0.004 | .067 | -0.050 | -0.106, 0.005 | .073 | -0.046 | -0.103, 0.011 | .11 | -0.047 | -0.106, 0.012 | .12 |
| Total hip | ||||||||||||
| (Constant) | 1.062 | 1.051, 1.072 | <.001 | 0.837 | 0.770, 0.904 | <.001 | 0.865 | 0.797, 0.933 | <.001 | 1.262 | 1.006, 1.517 | <.001 |
| Single MDD | 0.046 | 0.012, 0.080 | .008 | 0.029 | -0.001, 0.060 | .062 | 0.034 | 0.003, 0.065 | .030 | 0.034 | 0.003, 0.064 | .030 |
| Recurrent MDD | -0.004 | -0.047, 0.039 | .85 | -0.031 | -0.070, 0.007 | .11 | -0.028 | -0.068, 0.011 | .16 | -0.029 | -0.069, 0.012 | .17 |
| Total body | ||||||||||||
| (Constant) | 1.239 | 1.231, 1.247 | <.001 | 0.985 | 0.940, 1.031 | <.001 | 1.002 | 0.956, 1.048 | <.001 | 0.945 | 0.769, 1.120 | <.001 |
| Single MDD | 0.027 | 0.002, 0.052 | .037 | 0.012 | -0.009, 0.033 | .27 | 0.014 | -0.007, 0.035 | .19 | 0.017 | -0.004, 0.038 | .12 |
| Recurrent MDD | -0.009 | -0.040, 0.023 | .59 | -0.032 | -0.059, -0.006 | .017 | -0.032 | -0.059, -0.005 | .020 | -0.031 | -0.059, -0.003 | .033 |
Abbreviations: BMD, bone mineral density; MDD, major depressive disorder. Notes: Multivariable model 1 is adjusted for age and weight. Multivariable model 2 is adjusted for age, weight and current use of antidepressant. Final model is adjusted for age, weight, height, nutritional calcium intake and current use of antidepressants, bisphosphonates and calcium or vitamin D supplements.