Table 3.

Unadjusted and adjusted linear regression analyses between use of antidepressant and forearm, spine, total body and total hip BMD (g/cm²).

	Univariate models			Multivariable model 1			Final model
BMD/factors	B	95% CI	P value	B	95% CI	P value	B	95% CI	P value
Forearm
(Constant)	0.419	0.415, 0.424	<.001	0.360	0.331, 0.389	<.001	0.475	0.364, 0.587	<.001
Use of AD	-0.009	-0.026, 0.007	.27	-0.131	-0.224, -0.037	.006	-0.141	-0.233, -0.049	.003
Weight	0.001	0.001, 0.002	<.001	0.001	0.001, 0.001	<.001	0.001	0.001, 0.002	<.001
AD*Weight	-	-	-	0.001	0.000, 0.003	.010	0.002	0.001, 0.003	.003
Lumbar spine
(Constant)	1.296	1.282, 1.309	<.001	0.924	0.827, 1.021	<.001	0.608	0.241, 0.974	.001
Use of AD	-0.036	-0.086, 0.014	.16	-0.326	-0.622, -0.029	.032	-0.333	-0.627, -0.039	.027
Weight	0.003	0.002, 0.004	<.001	0.003	0.002, 0.004	<.001	0.002	0.001, 0.003	<.001
AD*Weight	-	-	-	0.003	0.000, 0.007	.062	0.004	0.000, 0.007	.043
Total hip
(Constant)	1.068	1.058, 1.079	<.001	0.868	0.799, 0.936	<.001	1.262	1.006, 1.517	<.001
Use of AD	-0.040	-0.077, -0.002	.039	-0.398	-0.603, -0.194	<.001	-0.414	-0.615, -0.213	<.001
Weight	0.004	0.004, 0.005	<.001	0.004	0.003, 0.004	<.001	0.004	0.003, 0.005	<.001
AD*Weight	-	-	-	0.004	0.002, 0.007	.001	0.004	0.002, 0.007	<.001
Total body
(Constant)	1.242	1.235, 1.250	<.001	1.001	0.955, 1.048	<.001	0.945	0.769, 1.120	<.001
Use of AD	-0.019	-0.047, 0.009	.18	-0.229	-0.371, -0.087	.002	-0.241	-0.382, -0.101	.001
Weight	0.004	0.004, 0.005	<.001	0.004	0.003, 0.004	<.001	0.004	0.003, 0.004	<.001
AD*Weight	-	-		0.002	0.001, 0.004	.004	0.003	0.001, 0.004	.001

Abbreviations: AD, antidepressants (current, no/yes); BMD, bone mineral density. Notes: Multivariable model 1 is adjusted for age and weight. Final model is adjusted for age, weight, height, nutritional calcium intake, MDD status, current use of bisphosphonates and calcium or vitamin D supplements.