Table 1.
Characteristics of various published cases of skull base radiation-induced osteosarcoma
| First author (year) [reference] | Age in years/sex | Primary tumor | Radiation dose (Gy) | Latency (years) | Site of radiation-induced osteosarcoma | Treatment | Survival period |
|---|---|---|---|---|---|---|---|
| Amine (1976) [32] | 16/F | Pituitary adenoma | 51.0 | 10 | Sella | Radiation | 5 weeks |
| Tanaka (1989) [33] | 57/M | Craniopharyngioma | 110 | 15 | Sphenoid wing | Embolization surgery | 2 weeks |
| Salvati (1994) [34] | 45/M | Pituitary adenoma | 44 | 12 | Sphenoid | Radiation (50 Gy) | 16 months |
| Gnanalingham (2002) [35] | 67/F | Pituitary adenoma | 52 | 14 | Sella | Surgery | – |
| Hansen (2003) [36] | 39/M | Pituitary adenoma | 52 | 22 | Sella, clivus | Surgery | Short |
| Bembo (2004) [37] | 45 | Pituitary adenoma | 46 | 5 | Sella | Surgery | 7 weeks |
| Patel (2011) [15] | 44 | Craniopharyngioma | 60 | 9 | Sphenoid-ethmoid sinus | Chemotherapy | 16 months |
| Yamada (2012) [38] | 75/F | Pituitary adenoma | 50 | 20 | Sphenoid sinus | Cyberknife surgery, chemotherapy | 24 months |
| Patel (2011) [15] | 54/M | Maxillary and adenoid cystic carcinoma | 60 | 12 | Sphenoid, frontal and temporal bone | Surgery, chemotherapy | 13 months |
| 63/M | Squamous cell carcinoma, nasal cavity | – | 4.5 | Palate + maxillary sinus | Surgery, chemotherapy | 47 months | |
| 50/M | Squamous cell carcinoma, nasal cavity | – | 14 | Infratemporal fossa | Surgery, chemotherapy | 17 years | |
| 44/F | Craniopharyngioma | – | 9 | Sphenoidal, ethmoidal bone | Chemotherapy | 18 months | |
| 15/M | Retinoblastoma | – | 15 | Zygoma | Surgery, chemotherapy | 62 months | |
| 22/M | Retinoblastoma | – | 20 | Ethmoid + maxillary sinus | Surgery, chemotherapy | – | |
| 10/M | Rhabdomyosarcoma | – | 6.75 | Mastoid + jugular foramen | Surgery, chemotherapy, radiation | 29 months | |
| 31/M | Rhabdomyosarcoma | 60 | 18 | Palate + infratemporal fossa | Surgery, chemotherapy | 143 months | |
| 26/M | Retinoblastoma | 35 | 25 | Surgery, chemotherapy | 41 months | ||
| Hansen (2003) [36] | 29/M | Pituitary adenoma | 5000 rad | 22 | Sphenoid, frontal clivus | Chemotherapy | Very short |
| Patel (2014) [39] | 52/M | Craniopharyngioma | 50 | 22 | Sella + clivus | Surgery | 1 month |
| Our patient | 28/M | Nasopharynx carcinoma | 70 | 11 | Sphenoid + maxillary bone | Chemotherapy | 6 months |
M male, F female, Gy gray