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. 2016 Dec 1;18:284. doi: 10.1186/s13075-016-1181-0

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Serum reactivity to multiple citrullinated fibrinogen (cit-Fib) epitopes. a. Pie charts indicate the proportion of serum samples that were reactive with multiple cit-Fib peptides. The total number of individuals is indicated in the centre of the pie chart. The p value indicates the result from a chi square test comparing the multiple reactivates in anti-citrulline protein antibody (ACPA)-positive vs ACPA-negative individuals. b. Illustration of the multiple reactivity seen in individuals positive for antibodies against each cit-Fib peptide. CCP cyclic citrullianted peptides