Table 1.
KEGG Pathway | Up-Regulated Proteins | Down-Regulated Proteins |
---|---|---|
Ribosome | – | RPL35, RPL7A, RPL29, RPL7, RPL3L, RPL19, RPL10, RPL13A, RPL8, RPL13, RPL4, RPS18, RPL34, RPS2, RPL21, RPL28, RPL35A, RPL24, RPL26L1, RPS8, RPL18A, RPL6, RPL23A, RPS13, RPL14, RPS5, RPS16, RPS27L |
Protein export | HSPA5 | SPCS2, SRPRB, SEC61B |
Protein processing in endoplasmic reticulum | RPN2, HSPA5 | SAR1A, SEC61B, SEC23B, RRBP1, CRYAB, HSP90AB1 |
Focal adhesion | THBS2, FLNB, COL6A1, ITGA8, MAPK3 | ACTN1, TNC, ZYX |
HIF-1 signaling pathway | SLC2A1, MAPK3, HMOX1 | ENO3, PGK1 |
ECM-receptor interaction | THBS2, ITGA8, COL6A1 | TNC |
PI3K-Akt signaling pathway | THBS2, GNG2, COL6A1, ITGA8, MAPK3 | TNC, HSP90AB1, GNG12 |