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. 2016 Oct 27;17(11):1787. doi: 10.3390/ijms17111787

Figure 9.

Figure 9

Treatment with 11-epi-SA induces HA22T cell apoptosis through two distinct pathways. (A) Two inhibitors, salubrinal (Sal) and SP600125, rescued the 11-epi-SA-induced cytotoxicity in HA22T cells. # p < 0.05; * p < 0.001; (B) Validation of altered protein expression caused by these two inhibitors. HA22T cells were treated with 11-epi-SA in the presence or absence of Sal (left) or SP600125 (right) for 24 h, cells were harvested and cell lysates were processed to assess ER stress-mediated pathways proteins as indicated by Western blotting using specific antibodies as indicated.