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. 2016 Oct 27;17(11):1798. doi: 10.3390/ijms17111798

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of ganodermanondiol (GN) on melanin production and cellular tyrosine activity of B16F10 cells. GN inhibits (A) melanin production and (B) cellular tyrosinase activity in B16F10 cells treated with various concentrations (2.5, 5, 7.5, and 10 μM) for 72 h. Values are means ± standard deviation (SD) of three independent experiments. Statistical significance of differences was evaluated using a one-way analysis of variance (ANOVA) followed by Tukey’s test. * p < 0.05, ** p < 0.01, and *** p < 0.001 versus B16F10 cells without GN treatment. A: arbutin (0.5 mM).