Table 1.
In vitro cytotoxicity of Pt1–6 and Pt1’–6’ against L1210 (murine leukaemia) and Du145 (prostate cancer) and A2780 (human ovarian cancer) cell lines. IC50 is the concentration at which cell growth is inhibited by 50% over 72 h. Values taken from reference [27].
| Complex | IC50 (µM) | ||
|---|---|---|---|
| L1210 | Du145 | A2780 | |
| Pt1 | 0.10 ± 0.01 | 0.08 ± 0.05 | 0.27 ± 0.03 |
| Pt1’ | 1.5 ± 0.1 | 0.79 ± 0.08 | 2.7 ± 0.07 |
| Pt2 | 0.009 ± 0.002 | 0.007 ± 0.002 | 0.030 ± 0.004 |
| Pt2’ | 0.46 ± 0.01 | 0.41 ± 0.04 | 1.1 ± 0.1 |
| Pt3 | 0.19 ± 0.01 | 0.44 ± 0.06 | 2.0 ± 0.1 |
| Pt3′ | 0.8 ± 0.2 | 2.7 ± 0.2 | 6.5 ± 0.0 |
| Pt4 | 1.3 ± 0.4 | 2.2 ± 0.1 | 3.7 ± 0.4 |
| Pt4′ | 6 ± 2 | 3 ± 1 | 2.0 ± 0.1 |
| Pt5 | 0.6 ± 0.2 | 1.3 ± 0.4 | 2.6 ± 0.2 |
| Pt5′ | 5.5 ± 0.1 | n.d. | n.d |
| Pt6 | 0.36 ± 0.02 | 0.12 ± 0.03 | 1.1 ± 0.3 |
| Pt6’ | 1.8 ± 0.0 | 1.5 ± 0.03 | 5.6 ± 0.5 |
| Cisplatin | 0.35–1 [a] | 1.2 ± 0.1 | 1.0 ± 0.1 |
| Carboplatin | n.d. | 2.9 ± 0.4 | 0.16 ± 0.0 |
| Oxaliplatin | n.d. | 15 ± 1 | 9 ± 3 |