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Composition and mucoadhesive characteristics of the chitosan hydrogel and comparison with control groups.
| Formulation | HPMC a (%, w/w) | Chitosan (%, w/w) | TBO (μM) | Mucoadhesive Strength b (N) ±SD |
|---|---|---|---|---|
| TBO | 0 | 0 | 20 | 0.77 ± 0.04 |
| Mixture of TBO and chitosan | 0 | 0.25 | 20 | 1.45 ± 0.07 |
| F-1 | 0.25 | 0.25 | 20 | 5.13 ± 0.09 |
| F-2 | 0.5 | 0.25 | 20 | 7.23 ± 0.34 |
a: HPMC: Hydroxypropyl methylcellulose; b: Each value is the mean from three independent experiments ± standard deviation; TBO: toluidine blue O.
