Table 3.
Correlation between preconditioning serum levels of soluble mediators and the peripheral blood cell counts tested before and following allotransplantation. The results are presented as the Spearman’s ρ and significant correlations (p < 0.05) are highlighted in bold. (Upper part) Significant correlations between IL-6 family cytokine levels tested before conditioning therapy and peripheral Boblood cell counts tested before immediately before initiation of conditioning treatment; (Lower part) Correlations between preconditioning serum mediator levels and peripheral blood cell counts (neutrophils and platelets) tested after allotransplantation. Time to neutrophil engraftment was defined as peripheral blood neutrophils above 0.2 × 109/L on three consecutive days and time to platelet engraftment as peripheral blood thrombocytes above 20 × 109/L on three consecutive days without platelet transfusions.
| Preconditioning Peripheral Blood Cell Counts | ||
| Peripheral Blood Parameter | IL-6 Family Cytokine | Correlation |
| Hemoglobin level | IL-6 | −0.40 |
| Total leukocyte count | OSM | 0.27 |
| Hematopoietic Reconstitution after Allotransplantation | ||
| Mediator | Neutrophils above 0.2 × 109/L | Platelets above 20 × 109/L |
| IL-6 | 0.12 | 0.19 |
| sIL-6R | 0.283 | 0.12 |
| sgp130 | 0.238 | 0.05 |
| Diff | 0.215 | 0.02 |
| CNTF | 0.19 | 0.01 |
| OSM | 0.01 | −0.06 |