Table 2.
Top ranked over-represented pathways shared by all DEP extract treatments following 4 h incubation. Functional enrichment was performed using ToppFun tool integrating numerous annotation databases. Significant upregulation resp. downregulation of genes: ↑↓.
| Name | Genes from Input |
|---|---|
| ”Benzo[a]pyrene metabolism”, ”Synthesis of bile acids and bile salts via 27-hydroxycholesterol”, ”Synthesis of bile acids and bile salts via 24-hydroxycholesterol”, ”Synthesis of bile acids and bile salts via 7α-hydroxycholesterol”, ”Synthesis of bile acids and bile salts”, ”Bile acid and bile salt metabolism” | ↑ AKR1C3, AKR1C2 |
| ”Metabolism of lipids and lipoproteins” | ↑ TXNRD1, GLIPR1, AKR1C3, AKR1C2; ↓ LDLR, CTGF |
| ”PPARA Activates Gene Expression”, ”Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) “ | ↑ TXNRD1, GLIPR1; ↓ CTGF |
| ”Retinoid metabolism and transport, Ovarian steroidogenesis” | ↑ AKR1C3; ↓ LDLR |
| ”Oxidative Stress” | ↑ TXNRD1, HMOX1 |
| ”Keap1-Nrf2 Pathway” | ↑ HMOX1, GCLM |
| ”Validated transcriptional targets of AP1 family members Fra1 and Fra2” | ↑ PLAU, HMOX1 |
| ”heme catabolic” | ↑ HMOX1 |
| ”Dissolution of Fibrin Clot”, Fibrinolysis Pathway”, ”Plasminogen activating cascade”, ”Blood Clotting Cascade”, ”Blood coagulation” | ↑ PLAU, SERPINB2 |
| ”Senescence and Autophagy” | ↑ IL24, PLAU, SERPINB2 |
| ”amb2 Integrin signaling” | ↑ PLAU; ↓ CTGF |
| ”DNA damage response (only ATM dependent) “ | ↑ PLAU, BIK; ↓ LDLR |
| ”intrinsic apoptotic” | ↑ BIK; ↓ BNIP3 |
| ”t(4;14) translocations of FGFR3” | ↑ FGFR3 |
| “Bladder cancer” | ↑ FGFR3; ↓ E2F2 |
| ”MicroRNAs in cancer” | ↑ PLAU, FGFR3, HMOX1; ↓ E2F2 |
| ”p38 signaling mediated by MAPKAP kinases” | ↑ HSPB1, SFN |