Table 3.

Top ranked over-represented pathways shared by all DEP extract treatments following 24 h incubation. Significant upregulation resp. downregulation of genes: ↑↓.

Name	Genes from Input
”Benzo[a]pyrene metabolism”, ”Synthesis of bile acids and bile salts via 27-hydroxycholesterol”, ”Synthesis of bile acids and bile salts via 24-hydroxycholesterol”, ”Synthesis of bile acids and bile salts via 7α-hydroxycholesterol”, ”Synthesis of bile acids and bile salts”, ”Bile acid and bile salt metabolism”, ”Steroid hormone biosynthesis”, ”Metabolism of xenobiotics by cytochrome P450”	↑ AKR1C4, AKR1C2
”Metabolism of lipids and lipoproteins”	↑ TXNRD1, AKR1C4, AKR1C2; ↓ HMGCS1
”ketone bodies metabolic”	↓ HMGCS1
”Selenium Pathway”	↑ TXNRD1, IL1B, KYNU
”thioredoxin pathway”	↑ TXNRD1
”Genes encoding collagen proteins”, ”Assembly of collagen fibrils and other multimeric structures”, ”Collagen biosynthesis and modifying enzymes”, ”Collagen formation”	↑ COL7A1; ↓ COL8A1
”Protein digestion and absorption”	↑ COL7A1, SLC3A2