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. 2016 Nov 3;17(11):1835. doi: 10.3390/ijms17111835

Figure 5.

Figure 5

Sal B up-regulates Glutaredoxin 1 (Grx1) but not Grx2 in RPE cells. (A) Dose-dependent effects of Sal B on Grx1 and Grx2 expressions. RPE cells were treated with (1–50 μM) Sal B for 24 h. Control cells were treated identically but without addition of Sal B. Bottom panel: The relative pixel density of Grx1 and Grx2 over glyceraldehyde 3-phosphate dehydrogenase (GAPDH). * p < 0.05 compared with the control group (n = 3); (B) time-dependent effects of Sal B on Grx1 and Grx2 expression. RPE cells were treated with or without Sal B for 2, 6, 12, and 24 h. Bottom panel: The relative pixel density of Grx1 and Grx2 over GAPDH. * p < 0.05 compared with the control group (n = 3); (C) dose-dependent effects of Sal B on Grx1 enzyme activity. RPE cells were treated with (1–50 μM) Sal B for 24 h. Control cells were treated identically but without addition of Sal B. * p < 0.05 compared with the control group (n = 3); and (D) time-dependent effects of Sal B on Grx1 enzyme activity. * p < 0.05 compared with the control group (n = 3).