Table 2.
X-linked miRNAs associated with RA polymorphisms.
| miRBase ID | Chromosome | Position (pb) | Gene | Location miRNA/Gene | Distance miRNA-Gene | RA SNPs | MAF |
|---|---|---|---|---|---|---|---|
| miR-221 | Xp11.35 | 45746157–45746266 | Foxp3 | Intergenic | ≈3.5 Mb | rs3761548, rs2232365 | 0.24, 0.41 |
| miR-222 | Xp11.3 | 45747015–45747124 | Foxp3 | Intergenic | ≈3.5 Mb | rs3761548, rs2232365 | 0.24, 0.41 |
| miR-532 | Xp11.2 | 50003148–50003238 | CLCN5 | Intragenic | - | NF | NF |
| Foxp3 | Intergenic | ≈733 Kb | rs3761548, rs2232365 | 0.24, 0.41 | |||
| miR-188 | Xp11.2 | 50003503–50003588 | CLCN5 | Intragenic Intergenic | - | NF | NF |
| Foxp3 | ≈500 Kb | rs3761548, rs2232365 | 0.24, 0.41 | ||||
| miR-98 | Xp11.2 | 53556223–53556341 | HUWE1 | Intragenic | - | NF | NF |
| let-7f-2 | Xp11.2 | 53557192–53557274 | HUWE1 | Intragenic | - | NF | NF |
| miR-223 | Xq12 | 66018870–66018979 | VSIG4 | Intergenic | ≈2868 bp | NF | NF |
| miR-652 | Xq23 | 110055329–110055426 | TMEM164 | Intragenic | - | NF | NF |
| miR-363 | Xq26 | 134169378–134169452 | Non coding gene | - | - | NF | NF |
| miR-92a-2 | Xq26 | 134169538–134169612 | Non coding gene | - | - | NF | NF |
| miR-20b | Xq26 | 134169809–134169877 | Non coding gene | - | - | NF | NF |
| miR-106a | Xq26 | 134169809–134169877 | Non coding gene | - | - | NF | NF |
| miR-3202 | Xq28 | 154019920–154019989 | TMEM187 | Intragenic | - | rs17422 | 0.41 |
| miR-718 | Xq28 | 154019920–154019989 | IRAK1 | Intragenic | - | rs1059702, rs1059703, rs1734792 | 0.37, 0.48, 0.42 |
Abbreviations: RA: Rheumatoid arthritis; SNP: single nucleotide polymorphism; MAF: Minor allele frequency; FoxP3: forkhead box P3; CLCN5: chloride voltage-gated channel 5; HUWE1: HECT; UBA and WWE domain containing 1; VSIG4: V-set and immunoglobulin domain containing 4; TMEM164: transmembrane protein 164; IRAK1: interleukin 1 receptor associated kinase 1; MECP2: methyl-CpG binding protein 2; TMEM187: transmembrane protein 187; NF: Not found.