Figure 1.

Illustration of the increase in complexity of the gene–protein relationship, starting from an oversimplified classic “one-gene–one-protein–one-function” model (top part, blue) and moving to more complex “one-gene–many-proteins–many-functions” scenarios caused by alternative splicing and PTMs affecting ordered proteins (middle part, pink) or intrinsically disordered and hybrid proteins containing ordered and intrinsically disordered domains (bottom part, red). Reproduced with permission from [45].