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Distribution of the mutation in IDH1 and MGMT promoter methylation among the patients according to their histopathological diagnosis (WHO II, III, IV). OS, Overall Survival.
| Astrocytoma II (n = 57) (Median OS, Month) | Astrocytoma III (n = 13) (Median OS, Month) | Glioblastoma (n = 13) (Median OS, Month) | ||||
|---|---|---|---|---|---|---|
| MGMT− | MGMT+ | MGMT− | MGMT+ | MGMT− | MGMT+ | |
| IDH1 pR132H | 33 (n = 11) | 47 (n = 24) | 28 (n = 5) | 47 (n = 7) | 22 (n = 2) | 22.5 (n = 6) |
| IDH1 WT | 21 (n = 11) | 19 (n = 11) | 14 (n = 1) | 0 | 7.5 (n = 4) | 2 (n = 1) |
