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. 2016 Nov 18;17(11):1901. doi: 10.3390/ijms17111901

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

The human immunodeficiency virus type 1 (HIV-1) broadly neutralizing antibodies (bNAbs) epitopes on envelope glycoprotein spike (Env) trimer. The surface representation of Env is derived from the crystal structure of BG505 SOSIP.664 (PDB no. 4TVP). Major HIV-1 Env epitopes are highlighted in different colors (CD4bs (red), V1/V2 (tv-blue), V3/Asn332 glycan patch (green), gp120/gp41-interface (wheat), MPER (denoted as gray rectangle)) and their representative bNAbs are listed in the right boxes. Other unspecified regions are in light grey for gp120 moiety and in dark grey for the gp41 moiety. The structural figure was generated with the program PyMOL (http://www.pymol.org/).